Live Interview with Drs. Edward Damiano and Steven Russell, creators of the Bionic Pancreas

Event Details

Live Interview with Drs. Edward Damiano and Steven Russell, creators of the Bionic Pancreas

Time: October 31, 2013 from 1pm to 2pm
Location: TuDiabetes homepage
Website or Map:
Event Type: live interview, videochat
Organized By: Emily Coles
Latest Activity: Nov 9, 2013

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Event Description

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Drs. Damiano and Russell are part of a collaborative group from Boston University and Massachusetts General Hospital working together to make automated blood glucose control a reality. Engineers from Boston University have developed a closed-loop artificial pancreas blood glucose control system that uses frequent measurements of blood glucose concentration along with subcutaneous delivery of both rapid-acting insulin and glucagon (to raise blood glucose, if necessary) as directed by a computer algorithm. The artificial endocrine pancreas automatically makes a new decision about insulin and glucagon dosing every five minutes. The system is being tested in people with type 1 diabetes at Massachusetts General Hospital, with results recently published in Science Translational Medicine (see Publications). 


Read more about the BionicPancreas

The Bionic Pancreas: coming soon 7/2013 Diabetes Daily

Sugar Fix  6/2013 Bostonian

The Bionic Pancreas  6/2013 DiaTribe

Turning Diabetes Over to the Bionic Pancreas 4/2013 Huffington Post

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Comment by Marie B on November 6, 2013 at 10:15am

The video has not been edited and uploaded yet. I'm sure when it's up, it will be featured, check back in a few more days.

Comment by Henry on October 31, 2013 at 9:14pm

I thought the videocast on the Bionic Pancreas was excellent. How can I watch it again now that it is over?
Cheers & Thanks

Comment by moof on October 31, 2013 at 1:41pm

I would like to see how well the bionic pumps works in individuals on a low-carb diet as suggested by Dr. Bernstein. My A1C is currently 5.4 on a low-carb diet while it was 7 when I ate a standard diet. While on the low-carb plan, keytones provide energy for my brain, muscles, and kidneys. This allows me to function well even if my blood sugar accidentally reaches extremely low levels such as 25 mg/dl. I would like to see your bionic pancreas have a mode where it can shoot for an average blood sugar of 110 versus 130, and allow manual boluses for protein and fat. protein and fat have a very large affect on my required meal boluses and post-parandial insulin required over the following 12 hours. No pump on the market has calculators with protein and fat in addition to carbs. Thank you.

Comment by Lyn wife of Type 1 on October 31, 2013 at 12:57pm

how do I get the video to starts? thx...

Comment by Biomuse on October 31, 2013 at 11:29am

P.S. The closed-loop-assist approach, by the way, takes some pressure off of the reliability of cgm data, getting us that much closer to a FDA-approvable product. Just sayin'.

Comment by Biomuse on October 31, 2013 at 10:53am

To clarify/sharpen my previous question: Given the kinetics of insulin dosing as it stands and the associated issues, the ideal system will be closed-loop-assisted, as opposed to closed-loop-only. Although the "guardrails" system (closed-loop-only) first needs to be tested and confirmed safe, the goal for a mature product should include user input at the pump. Is that on the drawing board and, if so, how far off are we from seeing its inclusion?

Comment by Denise on October 31, 2013 at 9:29am
5) Will the bionic pancreas be compatiable with faster-acting insulins as they come to market, such as Biodel's ultra rapid insulin that's in trials now?
Comment by Denise on October 30, 2013 at 3:44pm

4) Is the bionic pancreas pump going to be waterproof/sweatproof? I see this as important bacause the need for glucagon is there when swimming and doing activities that make people sweat.

Comment by Biomuse on October 30, 2013 at 9:41am

Interested to know whether this system is smart enough to land on its feet in the presence of user input at the pump, which would allow predictive dosing and very likely improve the average bg outcome.

Comment by Stephen on October 30, 2013 at 9:37am

Really looking forward to this! Apologies if my questions are overly technical.

Even fast-acting insulin has a relatively slow action time compared to other factors that control BG (at least for my pogo stick of a type 1 six year old!). How does the control algorithm deal with this, and what stability limits does this place on the system?

Similarly, what is the glucagon action time constant?

How does the system manage uncertainty around the CGM reading?

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