We were the ones that tried the experiment to activate the pod but not put it on the body...and see what insulin came out right away. I was shocked to see that when I tried it, nothing came out with the first .50 bolus...but the cannula did fill with insulin. So my guess was that this was not fully primed. My nurse tried it as well, but she got the pod to work perfectly right out of the gate. I think Gil on this forum used to work for Insulet and he said that some pods do not fully prime, so that insulin you think you are getting the first hour/hours after a new pod might just be filling the pod. In the past I have tried a bolus of anywhere from .5 to .75 with the new pod for my daughter just to "prime" it, then continued with the regular bolus for dinner (we used to change the pod right before dinner to see if it was working before bed).
The last few times we did that, it didn't go great. She was still high, but the pod did "kick in" later. So what I am doing now and actually causes me less stress is to change the pod AFTER dinner...so at least I know she gets her dinner bolus and doesn't spike to 300-400. I will do a higher temp basal after pod change to try to compensate for the priming issue. But I have found that by changing the pod after dinner, if she goes high it's only (usually) 200s because it's just the basal she might be missing for a while, and the insulin from dinner is still active for a couple hours as well.
We've had skin issues, PDM issues, pod failure issues that have all been resolved pretty much successfully. But this issue is by far the most problematic one of the Omnipod. It shouldn't have to be this hard!