You will have to be the judge, I would just purge the tubing if it had some big air pockets.
It's not uncommon for there to be a few champagne bubbles show up in the reservoir. When you fill
the reservoir all of the components need to be the same temp...I do not refrigerate my open bottle
of insulin and if I need a new bottle it comes out of the fridge the night before...I store my next res in
the same place as my open bottle of insulin. Remember the pump is a electrical device and the temp
inside the case can and will be higher than room temp (Ambient). Also it takes about 3" of tubing to
hold 1u of insulin so a small bubble is not a disaster for the average T1D. After some time you will
figure out what works best for you...there is some art involved with pumping insulin.