“There are so many unconfirmed scientific, peer-reviewed studies showing tentative benefits of supplements that have never been confirmed and followed by any satisfactory proof of worthwhile benefits to PWDs” would be more correct to me. I would challenge anyone to show just one such study (that has been confirmed and followed by a satisfactory proof of worthwhile benefits)
And, as assumed by the statement above, none of the studies linked above show confirmed and satisfactory proof of worthwhile benefits to diabetics. Let’s look at each of them.
As shown by your own quote, this one was so inconclusive that it could only “give a rational basis for evaluating vitamin E supplementation”, in other words, no proof and no benefits
The study you cite shows zero improvement to diabetes outcomes. In fact, it does not even evaluate them.
Furthermore, since the understanding of the roles of LDL and HDL is now in the process of being drastically revised, and many questions are now raised as to what exactly they mean to patients, it is very unlikely that increasing LDL oxidation in diabetes would be seen today by anyone as having a causal relationship to actual health improvement to diabetics.
You forgot to include the key sentence there: “None of the antioxidant measures (α-tocopherol, γ-tocopherol, retinol, TAR) showed protection against incident CAD overall.” This means there was no effect correlated to the amount taken.
How do the authors of the studies feel about their own findings? Do they feel this it warrants using these supplements? No. Their conclusion: “The specificity of these effects merits further investigation.” I don’t see that a very strong endorsement of your own study!
This 1991 publication has no follow-up studies or confirmation, nor consequences in terms of recommendations by any diabetes organizations. Ceriello himself never followed up: if you enter “Ceriello” and “Vitamin E” in Google Scholar you will find no followup to THIS study or further work on proof of efficacy with PWDs. I surmise that no long-term studies established the usefulness of vitamin E administration for prevention of diabetic complications after all
So, as you can see, none of these studies held up under scrutiny.
The reticence is due to the scientific process and the need for a standard of proof. They simply do not show the required proof of benefits to PWDs.
Here we both agree. If you would want to do so, it is a reasonable choice to decide that, even though there is no proof of effectiveness but only tentative possibilities, it is worth taking some supplements because the alternative has no upside.
I do want, however, to tell you the story of a very close friend who was diagnosed with stage 4 esophageal cancer. After 6 months of standard medicine and no improvement, he decided to go to an “immunotherapy” clinic in Texas, well known for its very high claims, its lack of scientific proof, and its very high prices (125K per treatment). I spent a few days researching it. He got irritated with me, the poor guy, and told me: “I understand that it is likely balloney. But what is my alternative?” I could not fault him. He went to the clinic, spent $125K, and died 4 months later.
So you should feel free to spend your money on these supplements. And who knows? There is always a chance that one of them will work for you!
But none of that warrants stating there is proof that any such supplements materially improve mainstream diabetes outcomes, though. That is simply not true!