Sorry, this one is pretty short compared to my other "cut the crap" blog posts. I really don't have a whole lot of free time and with the long discussion about the differences between humalog and novolog I thought it would be interesting to post something. Hopefully I didn't make any errors and it came out interesting.
There is a controversy right now among individuals about the differences between the two types of rapid acting insulin Humalog (Insulin Lispro) and Novolog (Insulin Apart). People claim they are the same, they are different and one works better than the other. This post will focus on the structure of the human insulin compared to each analog, and molecular mechanisms of each type, how they are formulated and how each should work. I'm not saying one is better than the other. The actions of each are specific to each person and the choice of insulin should always be a discussion between you and your physician. I have my personal preference and that's exactly it, my personal preference for how I control my disease.
The first thing is to distinguish between the different types of insulin. This post will focus specifically on 2 of the rapid acting insulins, Humalog and Novolog. I am working on another blog post about how long acting insulins work. While they are different, they can be used interchangably. Pharmacies will readily substitute one for the other if they are out and the patient does not have a strong preference. This has been my experience, yours may/will differ.
So how are Novolog and Humalog different from regular human insulin?
This is a very important topic and will take up the majority of this post because this will explain why one may work better than others. Endogenously secreted human insulin is a relatively simple protein. I'll bypass the synthesis and processing, if you want me to post about that please say so. Insulin is secreted as a...