As with everything in D, YDMV, your diabetes may vary. How insulin acts in me most likely will not be the same with you, but for me I just switched from humalog to apidra. While my CDE said they are equivalent in action and activity, I have found that humalog acts like a bull dozer, in 15 minutes it is already lowering my blood sugar, and if I am not high enough to begin with, or I do not eat enough carbs to cover the bolus, I will invariably end up with a hypo and it continues to act for close to 5 hours. In contrast, apidra acts more like a slow train, it takes longer to start working probably close to 1/2 hour, and does not cause the huge swings in my blood sugar. It also clears out of my system a lot faster, so within 2.5 hours it is gone. So if I totally mess up the carb calculation I can always correct a bit sooner with apidra. You said you have your I:C ratio at 1:10 but is that the same for every meal ? And also do you have an ISF or correction factor for the times your blood sugar is that high ?