Hi! I decided to join after reading several of your posts about MODY. My endo is working on getting me set up to get the 5 gene test from Athena. My insurance supposedly plans to cover it for me. I go back and forth between being sure I have a form of it, and other times I am afraid I'm just wasting time and money.
Basically what the family seems to be dealing with is normal fasting, borderline a1c, and high postprandials. My grandfather had diabetes diagnosed later in life (50s or 60s) and my uncle is dealing with the same. I recently discovered high postprandials in myself after having a few symptoms last year.... if I'm careful what I eat, I'm usually okay, but for instance I ate a serving of Peeps candy, and spiked a 212. My fasting is fine. My a1c is 5.6. I have four boys, and out of them two of my boys have a1c of 5.7 and 5.8. The one who has a 5.8 also has the best fasting and is also the skinniest...not an ounce of fat on him. By nature I am also slim...I did put on weight at certain times during my life, but currently I am back to slim. (BMI under 20).
The inheritance pattern seems related to MODY. My mother died in a car accident at my age, so I will never know if she would have developed symptoms. Whatever we have seems to be a slowly progressing form, and the fasting sugar stays really good for a long time, but evidently our postprandial numbers aren't too good. It sort of sounds like MODY2, except the fasting numbers are not elevated. It could also be a mild version, I guess, of MODY1. Probably not MODY3 because we don't spill glucose in urine, that I know of.
We are also of English/German/Irish decent. I am negative for antibodies. I also had a very mild gestational diabetes, controlled by diet, with all four pregnancies.
I'm nervous to take such an expensive test (there is a slight risk the insurance might screw up and decide not to cover it, I guess, even though the endo secretary spent 30 minutes on the phone making sure they would) if I don't have anything wrong with me. But it's just so strange that out of my four kids, two of them are already showing signs of a glucose intolerance. (The two that do not show these signs are overweight, Dad's genes, but have fine a1c's.)
Has anyone encountered a MODY that has healthy fasting but high postprandials, and slowly progresses as they near retirement age? I have researched a LOT online, and haven't been able to quite pin this down. I also emailed the place in Chicago to see if they had any insight but have not yet heard back.