Thanks again for your helpful information. It's been a couple of more months and I have learned more about the drug. It's my understanding that Genentech developed Lucentus from Avastin to formulate a smaller molecule with less side effects than Avastin. Anyway, we decided to go ahead with the treatment. He's had one shot already that only resulted in a temporary improvement. I think the anti-VEGFs show a lot of promise. It's likely that his eye condition has worsened a little bit because he has brought his bg levels down so quickly. The endo (no longer our doctor) that chewed us out for trying to normalize blood sugars actually dismissed the possibility that his eyes could be affected when I brought it up. Any sudden change in the body like dramatic weight loss, changes in bg levels can worsen retinopathy. Fortunately, his condition is still reversible , although as I'm finding out retinopathy can still progress no matter what you do. My son's insurance is willing to pay, but $2,000 a shot is a ridiculously high price.