Remember that Tresiba is insulin degludec
It is a different chemical structure from insulin glargine.
Tresiba pairs with the brain protein lysine, a different mechanism than other insulins.
And probably, degludec falls somewhere on the glutamate chain. The clue here is what happens with alcohol.
Alcohol also combines readily with the glutamate chain. They affect each other.
I'm not a physician or chemist. But three family members are glutamate intolerant -- and each one has a different, violent reaction to glutamic acid and/or alcohol.
So we have learned to avoid dextrose, maltodextrin and MSG, as well as alcohol, and some chocolate ice creams, the same way I avoid carbs now.
(Guess I am lucky I am the only one in my family who can tolerate glutamate, since I rely on Tresiba)
Another thing to be aware of that's not in the medical literature:
If Tresiba is combining with lysine-- can this have any effect upon someone with herpes or shingles?
As both those conditions can be helped by taking L-lysine supplements.
Something to think about.
Maybe someone more scientific than me can chime in about this.