Avandia, Actos, the FDA and Diabetics
When I see all the politics around this, I cannot avoid wondering what do you guys think? Anyone here taking any of these? How does this make you feel? Do you feel there's anything that could have been done earlier? When I read this other article, where the the incoming president of the ADA argues that he had been pressured by officials at SmithKline Beecham, I start to think that there could have...
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Permalink Reply by jims on
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Politics or not, I was in sad shape and kidneys failing and actos was only thing that seemed to get Blood glucose readings down.
Kidney Doctor wanted me off the Actos.
With extra hearty exercise and use of metformin to stop liver sugar production, I was able to get BG numbers dowm, get off Actos, get off starlix and get rid of 75/25 humalog and continue on humalog lispro normal small amounts with metformin.
A1c down from 13.3 to 6.9 and 6.4 today, kidneys stabalized, protein in urine stopped and far healthier.
The fact I have learned about actos is that yes it will stuff more glucose in the skeletal cells when insulin blocked by the same skeletal cells that are essentially full. Cells will die if overloaded with glucose and the oxidation byproducts and it is only normal for cells to ignore insulin if internal storage of glucose is full.
I am very glad to be off Actos as well as getting my situation under better control. - Attachments:
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Insulin_&why_meds_fail.doc, 246 KB
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Permalink Reply by Sandra Nichole Smith on -
Actos and GlaxoSmithKline’s Avandia, another medication prescribed for the treatment of diabetes, are members of the thiazolidinedione (TDZ) class of drugs. Currently the world’s best-selling diabetes medication, Actos became the leader in the diabetes-drug market after a 2007 study showed Avandia users have a 43% higher risk of having a heart attack.
Given the significant heart-attack risk linked to Avandia, the FDA has issued requirements mandating that doctors only prescribe Avandia to patients who have failed therapy with Actos. That may change, however, as the adverse effects of Actos become better known.
Here are the side effects and complication for actos. This might be your reference.
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