Actos and GlaxoSmithKline’s Avandia, another medication prescribed for the treatment of diabetes, are members of the thiazolidinedione (TDZ) class of drugs. Currently the world’s best-selling diabetes medication, Actos became the leader in the diabetes-drug market after a 2007 study showed Avandia users have a 43% higher risk of having a heart attack.
Given the significant heart-attack risk linked to Avandia, the FDA has issued requirements mandating that doctors only prescribe Avandia to patients who have failed therapy with Actos. That may change, however, as the adverse effects of Actos become better known.
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