I have been on Afrezza now for months. It is an ultra rapid insulin that is inhaled. I been on it now for 4 months and it has changed my life as I have no more worries of nighttime lows or lows throughout the day. When I was on Humolog / Novolog / Humilin my lows were daily. As we know this is a killer among diabetics as 1 in 20 will die from a low blood sugar.
Last year I almost went into coma 2 times and barely got revived the 2nd time. I also have had numerous lows rushing to the fridge on Novolog and Humolog. This all changed 4 months ago. I have been needle free for 4 months other than taking my daily Lantus. I have had 0 severe lows and only a few lows under 70 in 4 months. I have no daily swings over 250 readings anymore.. Why is this? It is because my management with Afrezza is so easy when I can adjust my blood sugar in minutes. Afrezza is about 90% out of my system in 30-40 minutes after taking it. So lets say I eat a late meal at 10pm. I can take my insulin and at 11pm before going to bed if my sugar is good I know its impossible for me to have a low at night. This has freed from all the stress and scares of lows.
Not only has it effected me this way but all my family members have noticed that I never have any emergencies or rushes for sugar..They all are able to sleep well with no worried about me during the night.
So why am I saying all this?
It actually makes me ill knowing that most people do not even know that this is coming and should of been available to all diabetics already. People die every day of low blood sugar. How about kids that have to damage this disease and the parents who are worried sick every night. I am not even sure how they can sleep. The inhaler is the size of my pinky as the pictures shows. I can have it in my pocket wherever I go and take the insulin anytime anywhere. The insulin is in powder form in the little cartridges.
For me controlling diabetes is now in real time as I dont have to wait 1-2 hours for it to start working and lingering on for 4-5 hours. If my blood sugar is 300 and I can adjust to 100 in 25 minutes. It is truly amazing and if anyone is reading this and has experienced lows please free to ask questions.
Makes me think about how people in today's time would have responded when BG testing first came out in the 1980's, needing a huge drop of blood, and took 2 minutes for the test. Initially visually read by color comparison, best you could tell was if you were around 80, 180 or over 240.
I think this product may be great for some, and may be limited in the initial release of 2 dosage sizes. But I hope like the BG meter, could evolve once/if the technology is proven.
And no, I don't own any stock, just open to possibilities.
If there was flexibility in dosage, convenient to use, and acted QUICKER than current insulins, I'd definitely consider using it. My biggest complaint is that bolus insulin works TOO SLOW.
All good points, though it seems to be the exact opposite of the 80/180/240 testing to today!
Your last paragraph makes sense and don't really understand why if one thing were possible the other wouldn't be!
AR, I understand that the numbers don't translate directly but I think the OP said it was like half so equivalent to 5 units and 10 units, still way more than many of us use! But it isn't just the size of the dose as the lack of options. After seeing the flexibility of the pump's precise doses vs whole units on MDI, it again, seems like going in the opposite direction.
From the time I read the original post I felt that it did not pass the smell test. It sounds like advertisement to me. But I can be cynical sometimes so I have kept my mouth.
I hope I'm wrong.
Ditto. I just couldn't put my finger on it well enough to report it.
To me, the dosage size seems like an "apples and oranges" thing. That doesn't bother me. I can also see that perhaps the large dosage is "made up for" by it not hitting as hard or something like that. I'd be intrigued to try it but I'd probably try it on something lower carb before I blazed away at donuts with it.
did anyone ever receive a response as to whether he owned stock?
NYSE said he can't say .... (smile)
I used Exubera and it worked a little faster but wasn't consistent.
I use a T-Slim pump now but if I have access to Afrezza I will try it. It would be nice to have an insulin absorb and be gone quickly. If I used that in conjuction with a pumped basal I could avoid more spikes and low night time blood sugars from insulin that waited too long to start working. Or who knows, maybe I would go back to injected basal ie lantus and use the Afrezza to bolus. If I watch my CGM I could inhale twice per meal ...
I'll try anything twice.....
Well as much as Ive enjoyed being advertised to, I have this awesome insulin called Humalog. It injects right through this cool device called a pump. They have these neat sensors so I wont die from low sugar (thank you poster for your lovely scare tactic there though!) If I can't afford a CGM there are lots of nice organizations that will give me a dog. I monitor my eating. I haven't had a truly dangerous hypo in a very long time. REALLY! I have an insulin to carb ratio. I don't use slide and scale anymore which is what this insulin sounds like it is asking you to do. My blood sugar sits from 80-110 all the time. I rarely go high, I rarely go low. I am not perfect of course, no one is, but this product seems rather ill conceived and this doesn't seem like a proper forum to drum up business. Really, seriously, its a little condescending and rude IMHO.
I was not aware the effects of inhaled insulin were that spectacular.... just afraid there may be lung damage so would adopt a wait and see attitude as it is a child that has Type 1, not willing to risk. Sounds amazing. I have not heard any reports on Oral Lynn which has been out in certain countries for a few years now and seems safer to me (absorbed through the buccal cavity of the mouth and does not effect the lungs. I will be watching reports on this insulin in the future. Thank you.
From a pre diabetic standpoint we have been trying to learn more about this product but also have questions about dosing. On their website they mention that the dosing will be available in 3, 6, and 9 unit equivalents to 3, 6, and 9 iu of humalog. They mention that a 12 unit single dose will likely be available in the near future as well. They also have a chart that shows insulin reaches half a peak after dose of 15 minutes with the dose 75% out of your system in 2 hours. They are indicating on the same chart that the equivalent dose of humalog takes 60 minutes and 5 hours to reach the same levels of insulin.
Am i missing something here? Can anyone with real world experience with humalong quickpen or novalog flexpen confirm these time frames and does it even matter if a person is on basel.
Thanks AfreezaUser, this sounds really exciting.
If you had hypos every day pre-Afreeza, then clearly your ratios were wrong, so any conclusions drawn about Afreeza versus normal insulin in this regard are invalid.
Coughing and residue left in the lungs could easily be a factor for asthmatics.
But I am absolutely PRO-inhaled insulin - because in the lungs the insulin has almost direct access to the bloodstream, whereas injected or pumped insulin must be gradually absorbed from the muscle you inject it into. This means that it acts quicker, and you spend far less time out-of range-after eating. To achieve this with current insulins you can use low-carb diets or inject ~10 minutes prior to your meal, but the tendency is to head up out of range. See http://www.managebgl.com/scenarios/should-I-inject-before-my-meal.html
Zoe - I agree that an accurate dose is critical, but presumably finer dosing will come with time - it's still very early stage. I too use very little insulin.
I would bet that far less than 30% of people are on pumps (more like 12-15%), and that the USA has the highest uptake. The tudiabetes and JDRF forums are populated by people who want the best control, which often involves pumps and CGMS, but not always (like myself). The high costs of pumps and consumables and lifestyle issues make them less prevalent than big pharma's marketing would like you to believe.