Replies to This Discussion

Permalink Reply by MegaMinxX on December 4, 2012 at 4:42pm

Makes me think about how people in today's time would have responded when BG testing first came out in the 1980's, needing a huge drop of blood, and took 2 minutes for the test. Initially visually read by color comparison, best you could tell was if you were around 80, 180 or over 240.

I think this product may be great for some, and may be limited in the initial release of 2 dosage sizes. But I hope like the BG meter, could evolve once/if the technology is proven.

And no, I don't own any stock, just open to possibilities.
If there was flexibility in dosage, convenient to use, and acted QUICKER than current insulins, I'd definitely consider using it. My biggest complaint is that bolus insulin works TOO SLOW.

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Permalink Reply by Zoe on December 4, 2012 at 5:07pm

All good points, though it seems to be the exact opposite of the 80/180/240 testing to today!

Your last paragraph makes sense and don't really understand why if one thing were possible the other wouldn't be!

AR, I understand that the numbers don't translate directly but I think the OP said it was like half so equivalent to 5 units and 10 units, still way more than many of us use! But it isn't just the size of the dose as the lack of options. After seeing the flexibility of the pump's precise doses vs whole units on MDI, it again, seems like going in the opposite direction.

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Permalink Reply by Stemwinder on December 4, 2012 at 5:02pm

From the time I read the original post I felt that it did not pass the smell test. It sounds like advertisement to me. But I can be cynical sometimes so I have kept my mouth.

I hope I'm wrong.

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Permalink Reply by Zoe on December 4, 2012 at 5:08pm

Ditto. I just couldn't put my finger on it well enough to report it.

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Permalink Reply by acidrock23 on December 4, 2012 at 4:55pm

To me, the dosage size seems like an "apples and oranges" thing. That doesn't bother me. I can also see that perhaps the large dosage is "made up for" by it not hitting as hard or something like that. I'd be intrigued to try it but I'd probably try it on something lower carb before I blazed away at donuts with it.

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Permalink Reply by pacard on December 18, 2012 at 4:57pm

did anyone ever receive a response as to whether he owned stock?

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Permalink Reply by garidan on December 18, 2012 at 8:16pm

NYSE said he can't say .... (smile)

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Permalink Reply by Jethro on December 19, 2012 at 4:14pm

I used Exubera and it worked a little faster but wasn't consistent.
I use a T-Slim pump now but if I have access to Afrezza I will try it. It would be nice to have an insulin absorb and be gone quickly. If I used that in conjuction with a pumped basal I could avoid more spikes and low night time blood sugars from insulin that waited too long to start working. Or who knows, maybe I would go back to injected basal ie lantus and use the Afrezza to bolus. If I watch my CGM I could inhale twice per meal ...
I'll try anything twice.....

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Permalink Reply by Alisonisayoshi on December 19, 2012 at 10:21pm

Well as much as Ive enjoyed being advertised to, I have this awesome insulin called Humalog. It injects right through this cool device called a pump. They have these neat sensors so I wont die from low sugar (thank you poster for your lovely scare tactic there though!) If I can't afford a CGM there are lots of nice organizations that will give me a dog. I monitor my eating. I haven't had a truly dangerous hypo in a very long time. REALLY! I have an insulin to carb ratio. I don't use slide and scale anymore which is what this insulin sounds like it is asking you to do. My blood sugar sits from 80-110 all the time. I rarely go high, I rarely go low. I am not perfect of course, no one is, but this product seems rather ill conceived and this doesn't seem like a proper forum to drum up business. Really, seriously, its a little condescending and rude IMHO.

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Permalink Reply by Jan on December 23, 2012 at 9:32pm

I was not aware the effects of inhaled insulin were that spectacular.... just afraid there may be lung damage so would adopt a wait and see attitude as it is a child that has Type 1, not willing to risk. Sounds amazing. I have not heard any reports on Oral Lynn which has been out in certain countries for a few years now and seems safer to me (absorbed through the buccal cavity of the mouth and does not effect the lungs. I will be watching reports on this insulin in the future. Thank you.

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Permalink Reply by Ron on March 7, 2013 at 1:45pm

From a pre diabetic standpoint we have been trying to learn more about this product but also have questions about dosing. On their website they mention that the dosing will be available in 3, 6, and 9 unit equivalents to 3, 6, and 9 iu of humalog. They mention that a 12 unit single dose will likely be available in the near future as well. They also have a chart that shows insulin reaches half a peak after dose of 15 minutes with the dose 75% out of your system in 2 hours. They are indicating on the same chart that the equivalent dose of humalog takes 60 minutes and 5 hours to reach the same levels of insulin.
Am i missing something here? Can anyone with real world experience with humalong quickpen or novalog flexpen confirm these time frames and does it even matter if a person is on basel.

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Permalink Reply by Simon Carter on April 21, 2013 at 7:13pm

Thanks AfreezaUser, this sounds really exciting.

If you had hypos every day pre-Afreeza, then clearly your ratios were wrong, so any conclusions drawn about Afreeza versus normal insulin in this regard are invalid.

Coughing and residue left in the lungs could easily be a factor for asthmatics.

But I am absolutely PRO-inhaled insulin - because in the lungs the insulin has almost direct access to the bloodstream, whereas injected or pumped insulin must be gradually absorbed from the muscle you inject it into. This means that it acts quicker, and you spend far less time out-of range-after eating. To achieve this with current insulins you can use low-carb diets or inject ~10 minutes prior to your meal, but the tendency is to head up out of range. See http://www.managebgl.com/scenarios/should-I-inject-before-my-meal.html

Zoe - I agree that an accurate dose is critical, but presumably finer dosing will come with time - it's still very early stage. I too use very little insulin.

I would bet that far less than 30% of people are on pumps (more like 12-15%), and that the USA has the highest uptake. The tudiabetes and JDRF forums are populated by people who want the best control, which often involves pumps and CGMS, but not always (like myself). The high costs of pumps and consumables and lifestyle issues make them less prevalent than big pharma's marketing would like you to believe.

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