I have been on Afrezza now for months. It is an ultra rapid insulin that is inhaled. I been on it now for 4 months and it has changed my life as I have no more worries of nighttime lows or lows throughout the day. When I was on Humolog / Novolog / Humilin my lows were daily. As we know this is a killer among diabetics as 1 in 20 will die from a low blood sugar.
Last year I almost went into coma 2 times and barely got revived the 2nd time. I also have had numerous lows rushing to the fridge on Novolog and Humolog. This all changed 4 months ago. I have been needle free for 4 months other than taking my daily Lantus. I have had 0 severe lows and only a few lows under 70 in 4 months. I have no daily swings over 250 readings anymore.. Why is this? It is because my management with Afrezza is so easy when I can adjust my blood sugar in minutes. Afrezza is about 90% out of my system in 30-40 minutes after taking it. So lets say I eat a late meal at 10pm. I can take my insulin and at 11pm before going to bed if my sugar is good I know its impossible for me to have a low at night. This has freed from all the stress and scares of lows.
Not only has it effected me this way but all my family members have noticed that I never have any emergencies or rushes for sugar..They all are able to sleep well with no worried about me during the night.
So why am I saying all this?
It actually makes me ill knowing that most people do not even know that this is coming and should of been available to all diabetics already. People die every day of low blood sugar. How about kids that have to damage this disease and the parents who are worried sick every night. I am not even sure how they can sleep. The inhaler is the size of my pinky as the pictures shows. I can have it in my pocket wherever I go and take the insulin anytime anywhere. The insulin is in powder form in the little cartridges.
For me controlling diabetes is now in real time as I dont have to wait 1-2 hours for it to start working and lingering on for 4-5 hours. If my blood sugar is 300 and I can adjust to 100 in 25 minutes. It is truly amazing and if anyone is reading this and has experienced lows please free to ask questions.
This insulin does sound like what we need. We need to stop the lows that can occur even with frequent basal testing. Our Type 1 seems to be extremely sensitive to the slightest amount of extra exercise (I am talking about walking, not planned exercise which we can easily take into account). I can see using it for meals and to correct highs. However, they definitely need to make smaller cannisters using much smaller amounts. But my question is: If you are using Lantus as your basal insulin, how do you prevent lows due to Lantus? Or highs. You can still go low on your basal insulin. And once you give a Lantus dose you're stuck with it; you can temp basal up or down as with the pump. You would be better off keeping the pump for basal insulin and using Affreza for meals and highs. I will be keeping my eye on this product after reading your amazing account of your experience. Thanks for informing us. I had thought inhaled insulin was not something worthwhile to consider.
I think we would all agree than insulin shots are the least painful aspect of diabetes. For me, finger pick blood tests are the worst.
Here is an interesting read about Exubera (the failed inhaled insulin),
http://curetype1diabetes.blogspot.com.au/2006_01_01_archive.html . In short, a cough, decrease in lung function, associated with a lower overall hypoglycemia rate but higher severe hypoglycemia rate, appearance of Exubera antibodies.
If I recall correctly, Afrezza has failed to "pass" FDA twice...
They should skip application to FDA altogether and try to market the drug in Europe first. FDA will hold release up for years. Once the drug is marketed in Europe it will be easier to get it through the FDA.... hopefully. This appears to be NOTHING like Exubera. Far superior; a true prandial insulin that mimics first-phase insulin response. I have seen nothing on Tu about Oral-lyn which is absorbed through buccal cavity of the mouth, bypassing the lungs entirely. That has been marketed overseas, not in Europe, in Latin America.
We have added modelling for Afreeza to ManageBGL's prediction system, and here are two sample scenarios:
One more concern..... If one should give the incorrect prandial dosage with Afrezza, would there be problems with hypos and not enough time to assess the situation and retrench? ICRs are more stable than basals but... different amounts of insulin for different foods, different ICRs based on exercise.... there is variability in bolus dosing as well. Working so quickly, at what point do you assess and either give carbs if necessary. We have been trained to test two hours after each meal and assess if more insulin is needed or more carbs. You would be surprised how the same meal different days does not yield the same results. This insulin is so quick; at what point do you check to see if your dosing was, in fact, accurate?