Apple's Steve Jobs with Type 1 Diabetes?
Could that be the cause of his visible weight loss in recent times?
According to Dr. Run Yu, director of the Carcinoid and Neuroendocrine Tumor Center at Cedars-Sinai Medical Center in Los Angeles, there are two likely explanations for Jobs' weight loss.
"A lot of this is speculative," Yu said to preface his reasoning, "since I don't know Mr. Jobs' condition specifically. But in terms of weight loss, and if the tumor was completely removed, it would be likely that he would have secondary Type 1-like diabetes. That's very common with patients who have had a large chunk of their pancreas removed. I see that very commonly."
More details:
http://www.computerworld.com/action/article.do?command=viewArticleB...
According to Dr. Run Yu, director of the Carcinoid and Neuroendocrine Tumor Center at Cedars-Sinai Medical Center in Los Angeles, there are two likely explanations for Jobs' weight loss.
"A lot of this is speculative," Yu said to preface his reasoning, "since I don't know Mr. Jobs' condition specifically. But in terms of weight loss, and if the tumor was completely removed, it would be likely that he would have secondary Type 1-like diabetes. That's very common with patients who have had a large chunk of their pancreas removed. I see that very commonly."
More details:
http://www.computerworld.com/action/article.do?command=viewArticleB...
Replies to This Discussion
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Permalink Reply by Anthony Holko on -
Dear John.
I dont know if this is in the right tread. But I was talking to my former collegue who has a PhD in process control and I also have a friend in Chemical process control at the University of montreal. They may not have diabetes but seemed to understand the disease. I was just wondering that if we have reliable pumps and accurate??? (i.e. not sure about that) on line BG sensors. We could link the 2 with a digital processor with appropriate software to calculate the insulin requirements automatically. You can fly a unstable jet at mach 2.5 even better without a human onboard. I wonder if I am dreaming since diabetes is more complex than flying a plane but then again a Trillion has been thrown at the easy problem and maybe not much at the difficult one. Imagine if the device gave you a weeks vacation from the disease.
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Permalink Reply by Jason on -
I think the big challenge with that is dealing with hypoglycemia. Since the islet cells aren't there to release glucagon, you would need a pump that could, along with insulin. And you can't mix the two substances in one reservoir, nor deliver them through the same infusion set.
Having two sites, one for CGMS and one for insulin, is a lot for me. But I may be willing to wear 3 if it meant a functional "cure".
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Permalink Reply by Anthony Holko on
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Dear Oneless.
This may be the crucial factor that we missed in our automatic control discussion in the glucagon loop not working in many diabetes. This is probably how a normal human keep their BG in the 70-110 range at all times is when the body over insulinates the glucogon feedback loop comes to the rescue. You wonder in the brittle diabetics if it is gone completely. ( as a side line I always wondered if over insulinating to get very tight control can finish off you glucagon loop causing brittle diabetes.?)
So another thing to wory about: how much insulin is you pancreas still producing, how insulin resistant are you and does you glucagon control loop still work somewhat.
Could be that some diabetics would be suitable candidates for automatic control and others would be difficult to treat.
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