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Permalink Reply by Cosumne Jan on July 27, 2012 at 12:32pm

jims, I downloaded and read your book a month or so ago. I only take 500 mg of metformin twice a day, but just changing the timing of when I took it, following your recommendation, brought my a.m. BS from the high 90s where it was drifting, back down to the low 80s. I always wake up precisely at 3 a.m. anyway (??) so it's no problem to take a met then. (I'm T2)

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Permalink Reply by jims on July 27, 2012 at 2:14pm

Thank you for reading my book.

The dosage that works as indicated by John Hopkins Childrens varies from person to person and apparently they claimed they had simple test to determine min dose that works.

At time of book writing, I was finding that on one generic met on my body , this would occur at 500 mg. On another did not work on standard 500mg - Teva.

Later ajusting dose up a little to 725 mg seemed to correct on the teva.

Generally my experience says that one wants the met up to strength by 3:00 am meaning 2 and 1/2 hours ingestion prior - 12:00 am through 12:30 am for best effect.

In any event be sure you work with your Doctor on this and not rely on my comments and data.

Thank you for your comments.

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Permalink Reply by Brian (bsc) on July 27, 2012 at 2:45pm

As a type 2, no amount of metformin was ever able to bring my fasting numbers down or address my Darn Phenomenon. I also tried stacking all the metformin (up to 2500 mg) at night and it still wasn't effective. While it is worth trying, someone who is already on 2000 mg of metformin and has progressed to MDI probably won't see much difference. Certainly worth a try, but.

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Permalink Reply by jims on July 27, 2012 at 7:47pm

Interesting comments.

Single large doses - 1000 mg up at night never worked on my body.

What in fact did was the 500mg dose at 10:00 pm and the dose at 12:00 am that worked. Otherwise dawn phenominum just kept cranking.

so far the two doses i take hold off liver glucose from 12:30 midnight clear through 5:30 am. The key being keeping the met dose up to strength over the stated time priod.

John hopkins childrens also stated that this met feature works on some and not others and simple test they have can tell who will be successful.

If the dose take is slightly smaller than that needed; liver will not cut off. Also residuals from large dose do not affect liver cutoff -only met up to sufficient strength in blood system does and for the run time. Typically standard met has a 2.5 hour up to strength time and a lasting time at strength of 1 to 3 hours. For me it was always 2 hours.

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Permalink Reply by Doris D on July 27, 2012 at 9:37am

Phil yes it does. I've been doing the bs check for maNY YEARS AT 3 AM WHEN i TEND TO RUN HIGH OR LOW IN THE MORNINGS. yES IT WILL HELP IT BUT PLEASE KEEP A WATCH ON UR BS'S IN THE MORNING U DON'T WANT TO GO TO LOW EITHER stupid caps now I'm doing what Linda does in chart. Sorry!

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Permalink Reply by Ruth on July 28, 2012 at 2:21pm

I'm sorry, Philmore, but I don't remember what you said in your other post about this. The one thing I would suggest it to make absolutely sure this is Dawn Phenom, and not a rebound high (somogyi effect). The way to do that is also to wake up at 3AM and test...if your blood sugar is low at that time, then your morning highs are a result of rebound, not Dawn Phenom. In that case, the answer is to have a snack containg some protein before bed.

Ruth

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