Glucose Kills Brain Cells After Severe Hypoglycemia
"The Diabetes Center at UCSF is proud of its partnership with diabetes researchers and clinicians across all UCSF campuses, hospitals and research centers. These complementary “neighborhoods” are helping to drive research in numerous directions – all focused on improving the lives of those living with diabetes. One physician researcher located at the Veterans Affairs Medical Center (VAMC) in San Francisco has long been interested in the challenging problem of diabetic hypoglycemia, or severe low blood sugar. Ray Swanson, MD, Chief of Neurology and Rehabilitation at the VAMC, and his colleagues have learned through animal studies that brain damage -- thought to be caused by severe hypoglycemia -- actually occurs when glucose is administered to treat the low blood sugar. Furthermore, it appears as though high levels of glucose given right after hypoglycemia is more damaging than a slower return to normal glucose levels. Even though these studies were in animal models and haven’t been investigated in humans yet, the findings were surprising and may have clinical relevance for the treatment of hypoglycemia in an emergency room situation. Dr. Swanson’s full study can be found in the Journal of Clinical Investigation . [ journal article ] [ Dr. Swanson ]"
Replies to This Discussion
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Permalink Reply by Zoey Stevens on -
Yeah it does!
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Permalink Reply by Scott on -
That's interesting. Something kind of similar was discovered a while back about oxygen starvation(ie drownings, etc). Most of the damage occurred when oxygen was re-introduced t0o quickly to the brain, not necessarily from the oxygen starvation itself
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Permalink Reply by Jason on -
This, according to the study, only happens after very severe hypoglycemia which causes coma and left untreated, death.
"The degree of HG modeled in the present studies is extreme, corresponding to the clinical setting of deep hypoglycemic coma in which blood glucose concentrations often fall below 1 mM, and brain glucose concentrations fall to near zero. "
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Permalink Reply by Josephine on -
I find it interesting that Lois was doing these treatments, maybe I read it wrong, not quite getting the picture, but it seems really freaky to me. I can't understand the English involved here.
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Permalink Reply by Anthony Holko on -
You have it right it is freaky.
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