I was one of 36 people selected to participate in the Canadian Edmonton Protocol at the University of Minnesota. I received two sets of islet (beta cell) transplants. I was insulin free for one year and that was wonderful. I was required to take immune suppressants for five years to prevent rejection. The latter have several side effects many of which can be quite severe. In my case, I had severe, persistent mouth ulcers that made my new non-diabetic diet far less enjoyable than it might have been. However, midstream my immune suppressant regime was changed and for three years I had no major mouth ulcers. After the one-year honeymoon of no insulin, I was required to take one daily insulin injection of Lantus and maintained normal blood sugars. From 2003-2008 I had NO hypoglycemic events. That was the best part of this treatment. I never worried about having hypoglycemia no matter what I did. My islets apparently died and I returned to full-fledged Type I DM in 2008. I would love to try the Islet Sheets and hope they will be available for humans shortly.