Hey folks, I'm pretty sure this topic has been covered to death but what can I say, I love to hear myself talk.
Anyway, I'm considering switching from twice daily NPH injections to Lantus. I tried this once before several years ago, and the upshot is: It was one big hypoglycemia coma. So, I'm a little nervous about the idea. I've been gathering as much info as possible on Lantus and I found the official dosing guidelines here: http://products.sanofi-aventis.us/lantus/lantus.html#section-3
The advice from Sanofi-Aventis is to take 80% of your total
daily NPH in Lantus. Maybe I'm nuts, but this seems like a lot
of insulin. I'm taking a 2nd NPH injection daily because the 1st one only lasts about 12 hours. So, if you take 10 units of NPH twice, at any given time during the day you should have about 10 units worth in your system, never 20 (ignoring the crazy peaks of NPH). But here they are suggesting that 18 units is appropriate, to minimize the risk of hypoglycemia no less. That's nearly double the old dose. So that would seem to explain the constant lows when I tried it before.
Anyone else run into this when switching from NPH? Am I the only one that thinks this advice is just a little wacky? Could it be they suggest doubling up in order to slow absorption so the stuff will actually last 24 hours?