LDN - low dose naltrexone
I am not a good or consistent blogger, but I felt the need to bring this information to the attention of as many people as I could. I have been hearing about the beneficial affects of a prescription drug called Naltdrexone on immunity related diseases for some time now. Usually it is related to multiple sclerosis, but it is increasingly credited with helping people with any kind of immunity disease. As with many unpatentable treatments, it does not get much press or support by the medical community. A video has been made by the son of Herman Wouk, which is excellent in explaining how and why LDN works, and why everyone who has an autoimmune disease should look into it. I plan on trying to get some from my physician based on the success Mr. Wouk has experienced. His name is Joseph Wouk, and you can see his video at: http://video.google.com/videoplay?docid=4440379733824898139. This could be a very important breakthrough for many of us who continue to develop autoimmune complications.
Tags: Joseph, LDN, Wouk, naltrexone
Replies to This Discussion
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Permalink Reply by Cleo on -
Hi Manny,
There are many on-going trials of LDN underway, but none for diabetes that I am aware of. However, the fact that LDN has been effective for so many different types of autoimmune diseases, with nothing in common except that they are autoimmune diseases, makes me wonder, why should T1 diabetes be any different? LDN 'normalizes' the immune system and halts the inflammation process. On that logic, I am willing to start taking LDN (which has no known serious side effects), on the probability that I might save some of my beta cells. If future trials show it doesn't help T`1's, I will have lost nothing. Just my POV.
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Permalink Reply by Jason on -
That isn't logic, it is merely wishful thinking. I would advise against taking any drug that has not been proven to successfully treat the condition you are taking it for. You are putting yourself at risk for no apparent benefit.
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Permalink Reply by Jason on
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The long-term effects of LDN are presently unknown. In many ways, that is worse than a known risk. I know it can cause problems for sufferers of MS.
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Permalink Reply by Yvonne on -
Has this drug been tested on cats? My cat has feline stomatitis and her cyclosporin is very expensive. I'd put her on interferon if I could afford it. I have arthritis and diabetes. I'd love to slow the progression of my arthritis and help my kitty.
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Permalink Reply by Cleo on
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I don't know about cats, but I know that people are using it for dogs.....the LDN Yahoo group would be able to direct you if you want to get more info....
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Permalink Reply by Cynthia D on -
Hi Cleo,
Thanks for bringing LDN to the forefront. I developed autoimmunue diabetes from an undiagnosed 26 year Hepatitis C infection which I just cleared. I took LDN for the first time last night and my BG was 80 upon awakening, the lowest it has ever been. This might be a coincidence but LDN's function is to modulate the immune system so it will stop attacking the islet cells of the pancreas.
I believe that several seemingly different diseases stem from the malfunctioning of the immune system when it turns on itself. I'll keep you updated on progress.
Cynthia D.
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Permalink Reply by diana on -
hello cynthia
i hope the ldn will work for you and help you.
it will be a huge success to u and others in this condition/
please, if u dont mind to keep me allso informed about how u feel, what changes do you expirience, any symptoms etc.
p.s. what doseg do you take?
all the best and good luck
diana@bezeqint.net
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Permalink Reply by Peter Yates on -
http://www.lowdosenaltrexone.org/_conf2006/P_Crowley1.mov
Here is a video of including the guy who discovered its application. People with MS are looking into it big time and it is now getting research funding from NIH for Crohn's disease. This research has started at Penn Sate including on kids between 6 and 17. MS and Type1 have been linked with research. Peope with either have a much greater risk of getting the other. In MS the immune system attacks the protective covering of nerves in the brain and spine. In Type 1 as we know it attacks the beta cells.
It is also being used to treat ruhmatoid arthritis. That's the autoimmune system one.
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Permalink Reply by Peter Yates on
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Here is some info on it as it applies to MS.
http://www.msrc.co.uk/index.cfm?fuseaction=show&pageid=651
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Permalink Reply by Peter Yates on
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A great demonstration is the sucess shown in Chrone's disease at Penn State.
If it could have the same effect on pancreatic cells and return them to health. Maybe it would only help early on in the honeymoon period or at least help retain some pancreatic function.
Past Completed Clinical Trials of Low Dose Naltrexone
> Penn State Trial for Crohn's Disease
Endoscopic Improvement in Crohn’s Colitis with Naltrexone
See attached files
Figure A: Shown is the rectum of a subject with active Crohn’s Disease before starting therapy with naltrexone 4.5 mg/day. The mucosa is ulcerated, edematous, and inflamed.
Figure B: Shows the same area of the rectum in the same patient four weeks after naltrexone therapy. The lining is now healed, ulcers resolved, and the mucosa is healthy.
Copyrights: do not reproduce the above images and captions without written permission from Jill P. Smith, MD, Professor of Medicine, H-045 GI Division, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033
The report on this groundbreaking research—"Low-Dose Naltrexone as a Treatment For Active Crohn's Disease"—was presented on May 23, 2006 at Digestive Diseases Week, a prestigious gastrointestinal conference, by Professor Jill Smith of the Pennsylvania State University College of Medicine. Dr. Smith's research paper, "Low-Dose Naltrexone Therapy Improves Active Crohn’s Disease," has been published by the American Journal of Gastroenterology in its January 11, 2007 edition.
Dr. Smith and her colleagues concluded that "LDN therapy offers an alternative safe, effective, and economic means of treating subjects with active Crohn's disease."
According to the news from Penn State, the National Institutes of Health has already granted $500,000 for Dr. Smith's group to continue the study. This funding should help assure a full-fledged placebo-controlled scientific trial of LDN in Crohn's disease. (Notably, Dr. Smith and her research teams are also involved in exploring the direct effects of using a form of endorphin by infusion in order to treat pancreatic and colon cancer.)
Note the treatment for pancreatic cancer. - Attachments:
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jsmith_figA.jpg, 138 KB -
jsmith_figB.jpg, 129 KB
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