Hello all-

I was just wondering, should I be taking my Metformin before meals (like 10-20 minutes) or can I take it as I'm eating or just after I've finished?  I don't know if it is important to get it "onboard" before I put food in my belly or if I can just take it whenever.  Do any of you know?

PS- I am back to eating.  5 days of fasting and I finally was able to keep something "real" down.  Hubby is happy which makes me happy because MAN! does he whine!!!  :)

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Tags: 2, diabetes, met, metformin, oral, type

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Hi Devon, I take mine, twice a day, at about 12 hour intervals 5:15 am and 5:45 pm. I am having execelent results the am is just after eating and the pm is before eating, supper time varies but my other meals and snacks are by the clock.
In my view, metformin's primary beneficial effects build up over time. You don't time the medication to obtain the benefits, you time the medication to minimize the side effects. Everyone is different. Some people may find that they have lessgastric distress if they take the metformin with food, others minimize distress by taking it without food. I would just choose whatever works best. I take a maximum dose, 1g in the morning and 1.5g in the evening. Although I have certain gastric issues, metformin does not bother me.

One thing that you should be aware of is that one of the effects of metformin is to impede the absorption of carbs and for some people I've heard taking metformin with carby meals can amplified some gastric issues.

Hope that helps.
Devon, I'm on Glumetza in lieu of Metformin (TOO MUCH stomach upset for me) and take it twice a day (as of recently in conjunction with insulin)--with breakfast and dinner. I find that if I take it literally at the first bite of food, or midway into the meal, I have less side effects. Other than that, I don't think that timing will affect the medication and it's benefits...
I also take it right after the first bite. I also find the stomach issues less severe if I take it right when I start to eat
I am on the ER version and I usually take it after dinner with the rest of my evening meds unless we had a really late meal.

Past the first week or so I really haven't noticed any gastric side effects... with or without food hasn't seemed to matter.
After eating for me. Stomach upset if I didn't have food in my stomach. I am also on Glumetza, and this decreased the stomach upset for me.
I take mine after I eat because I was told to take it with a full tummy. Glad you are finally better - I won't ask about the chicken! :)
I'm taking mine once daily (lunch)...and take it just after my first bite. Before, I took it before the meal...but had some stomach upset.
Very cool. I didn't realize it was a cumulative thing, I thought it was like insulin. Good to know. Thanks!
Metformin will reach full effectiveness in 6-8 weeks. It has three primary effects (http://en.wikipedia.org/wiki/Metformin#Mechanism_of_action).

First, it reduces the amount of blood sugar produced by your liver, this presumably will decrease you basal needs and help your fasting numbers.

Second, it increases the insulin signaling resulting in increased insulin sensitivity. The effect is primarily on the muscle mass in your body. Insulin resistance also affects all kinds of other stuff, but the biggest utilization of insulin is in the uptake of glucose to muscles.

Third, it decreases the absorption of glucose during digestion. It is this effect that I believe causes some of the gastric issues. By enabling carbs and sugars to proceed further down your digestive system, the natural flora then goes wild fermenting all that good sugar generating gas. This is perhaps why some people call it "metfartin."
"metfartin" - love it.
metfartin is right! glad I don't have to take it.




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