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Permalink Reply by Stemwinder on February 10, 2013 at 2:52pm

I sorry Don't know much about MODY. Here are a few resources you might try.
http://www.isletsofhope.com/diabetes/symptoms/maturity_onset_diabet...
http://diabetes.niddk.nih.gov/dm/pubs/mody/
http://www.tudiabetes.org/group/monogenic-diabetes-aka-mody

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Permalink Reply by vsanthuff on February 10, 2013 at 3:02pm

thank u so much Stemwinder. i am trying to see if this is something i should have him checked for

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Permalink Reply by Holger Schmeken on February 10, 2013 at 3:24pm

Just out of curiosity: what makes you believe he might have mody instead of T1?

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Permalink Reply by vsanthuff on February 10, 2013 at 3:47pm

he has 4 gen. of diabetes. he does not take alot of insulin. has negative antibodies.

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Permalink Reply by Mishi on February 11, 2013 at 12:04am

Yes your son can get ketoacidosis from Mody HFN and i would test for ketoacidosis,I have two cousins who have the Mody HFN genes.One is 100% insulin dependent and the other takes combi oral and insulin and both in there time have had DKA also.HFN and gentic T2 i can trace in my family back 6 generations and only effects females with in the family,Effcts of early ketoacidosis are very tired and sleepy,weakness
great thirst,frequent urination,dry skin and tongue,leg cramps,fruity odor to the breath,constant upset stomach and nausea.In japan as most T-box genes encode we test for MODY HFN more often and we have the highest amount of it in world.

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Permalink Reply by vsanthuff on February 11, 2013 at 4:34am

ty. we check him alot but he has never had them. he has been a diabetic for 8 years and on his lantis he takes 7 units. the other kids we know take 20-30 units. i wish they would check it here.

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Permalink Reply by Brian (bsc) on February 11, 2013 at 5:31am

MODY is what is called autosomal dominant, you only need to get the gene from one parent. This means that a child with MODY will have an unbroken line of ancestors with MODY. This is different than the genetics of T2 and T1, where not everyone with the genes necessarily gets the disease. Each MODY form is different. There are new forms discovered all the time. MODY-2 (GCK) is characterized by chronic high fasting blood sugars and a delayed release of insulin at meals. The other forms are generally characterized by poor responses to meals, but reasonable fasting levels.

Only 85-90% of T1s test positive for antibodies. If your son has been tested for c-peptide and is insulin deficient, it is unlikely he is MODY even with negative antibody tests.

You should join the MODY group Stemwinder mentioned where there are a number of good information resources.

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Permalink Reply by vsanthuff on February 11, 2013 at 7:31am

thank u

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Permalink Reply by Mishi on February 11, 2013 at 10:56am

BSC Your wrong depenedent on form of HFN,As most who have mody have to be tested for a Gene pool problem,As testing is consistent with 6 main strains but there are 36 other types of HFN,,MODY2 is often diagnosed in association with pregnancy with gestational diabetes, obesity, or old age and not the way you express it.What you are quoting is very very very rare in a child.

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