Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells
Research abstract published in BMC Medicine
Inability to control autoimmunity is the primary barrier to developing a cure for type 1 diabetes (T1D). Evidence that human cord blood-derived multipotent stem cells (CB-SCs) can control autoimmune responses by altering regulatory T cells (Tregs) and human islet β cell-specific T cell clones offers promise for a new approach to overcome the autoimmunity underlying T1D.
We developed a procedure for Stem Cell Educator therapy in which a patient's blood is circulated through a closed-loop system that separates lymphocytes from the whole blood and briefly co-cultures them with adherent CB-SCs before returning them to the patient's circulation. In an open-label, phase1/phase 2 study, patients (n = 15) with T1D received one treatment with the Stem Cell Educator. Median age was 29 years (range: 15 to 41), and median diabetic history was 8 years (range: 1 to 21).
Stem Cell Educator therapy was well tolerated in all participants with minimal pain from two venipunctures and no adverse events. Stem Cell Educator therapy can markedly improve C-peptide levels, reduce the median glycated hemoglobin A1C (HbA1C) values, and decrease the median daily dose of insulin in patients with some residual β cell function (n = 6) and patients with no residual pancreatic islet β cell function (n = 6). Treatment also produced an increase in basal and glucose-stimulated C-peptide levels through 40 weeks. However, participants in the Control Group (n = 3) did not exhibit significant change at any follow-up. Individuals who received Stem Cell Educator therapy exhibited increased expression of co-stimulating molecules (specifically, CD28 and ICOS), increases in the number of CD4+CD25+Foxp3+ Tregs, and restoration of Th1/Th2/Th3 cytokine balance.
Stem Cell Educator therapy is safe, and in individuals with moderate or severe T1D, a single treatment produces lasting improvement in metabolic control. Initial results indicate Stem Cell Educator therapy reverses autoimmunity and promotes regeneration of islet β cells. Successful immune modulation by CB-SCs and the resulting clinical improvement in patient status may have important implications for other autoimmune and inflammation-related diseases without the safety and ethical concerns associated with conventional stem cell-based approaches.
ClinicalTrials.gov number, NCT01350219.
Thanks for this post, Emily. I think that this research, thpugh the study group was limited is a further indicator that medical interventions in the future for Type one diabetes and ,other autoimmune disorders, WILL be morer will yield positive reuslts. I do expect there will be a "cure", or close to it, in my lifetime. And I am 57 with type one for 43 years..... I truly believe that our bodies can heal themselves, we were made that way....but we just do not know how, YET.
I agree that the body is designed to heal itself and we just haven't figured out the how, yet. I wonder if anyone with T1, anyone else I mean, is trying to figure this out on their own?
Lasting improvement is vague. I wonder if any the recipients were actually off injected insulin for some time?
I've corresponded with the lead researcher in this study in a brief email. I was not able to obtain really any info from him other then what was published in that article which is now a few months old already. He noted they were working towards filing an IND in the US and hopefully getting the go ahead in the near future, I don't think any of the patients in the trial were able to get off insulin but all patients were able to reduce insulin dosage significantly which is pretty impressive. I won't get over excited about this just yet but the results speak for themselves.
This method of rehabilitating the T-cells is amazing. However, the root cause of the T-cells corrupting to begin with is unknown.
This makes me wonder if reactivating the bodies own thymus would also have similar effect. The thymus destroys T-cells that have corrupted but the thymus seizes to function at the onset of puberty. Could added hormones in the food trigger an early termination of the thymus?
They are on the right track anyway.