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The results are in for my C-peptide and IgG, and I am very pleased!
(Please see my previous discussions for a long narrative on why I had these tests run.)

The C-peptide was 3.8 (reference 1.1-4.4)
GAD65 was 0.00 (reference <0.02)
IgG was <1:4 (reference <1:4)

So, if I am reading this correctly, I have no antibodies to suggest an autoimmune attack on my pancreas, correct?

As far as the C-peptide, I am assuming this means I am making adequate insulin on my own. I know this particular test is not the most accurate in the world, but it does tell me that I make at least some of my own insulin, right? Since it is in the normal range, I am wondering if that means I have a lot of insulin resistance?

By the way, this test was not fasting, I had eaten some oatmeal about 2 hours before the test.
My medications are 1,000 mg of Metformin daily, 1.8 mg Victoza nightly, and 32 units of Lantus nightly. Not sure how any of the above factors would have affected the test results.

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This would indicate that you are a Type 2. It also shows that you are still producing insulin. A Type 1 (or Type 1.5 for adult onset) would have the antibodies. It also would have a negligible or C-peptide number (although at the beginning stages it might be in a low normal range as the pancreas is shutting down production). Eating should not affect these tests. The medication would not either.
That is what I thought. I am firmly a T2, and given my family history of both types, I definitely wanted some answers. I am grateful this answered that question for me!
Donna, I have to disagree with your statement that sparkysmom's medications would not affect her tests. Since Victoza prompts the pancreas to produce insulin in response to glucose in the blood, one would expect an elevated C-Peptide, 2 hrs after a meal. Another effect is to decrease the livers output of glucose, this might explain her decreased basal insulin needs.
Congratulations Sparkysmom. I'm so glad that you were able to find out what is going on. While I'm not clear on the meaning of the numbers myself, Donna's response sounds hopeful. I can only imagine how the uncertainty affected your progress. How are you doing now? Are you getting good readings most days? Joanne
Thanks, Peetie! I am actually getting very good numbers. I have been able to titrate my Lantus down to 32 units nightly over the last couple of weeks, from 40 units. Of course, my all-time high of Lantus was 75 units before the Victoza was started, so I feel like the Victoza is mostly responsible for this ability to decrease the Lantus.

My morning numbers are anywhere from 90-110, so I'm very happy with that.
Sounds great, sparkysmom!

C-Peptide is a by product of the production of insulin. Since you were not fasting it is to be expected your number would be highish if you are producing insulin. Here's a good explanation of what C-Peptide means and how to interpret results depending on if it is fasting or not. It would be interesting to know what your blood sugar was at the time of the test.

Some people think C-Peptide helps protect against complications, so your result may be a positive.

I know the antibody tests are not fool proof, but they would point to T2 which means you have insulin resistance by definition.

I love playing arm chair endo, it will be interesting what others say.

I agree with the others, it looks like a pretty good indication of Type 2. What have your doctors said? Having gone through the process of being unsure of type myself, I know what a relief it can be to know!

How is your management going currently?
Zoe, see above for my response to Peetie. I am very, very pleased with my results this last week, since I have leveled off to about 32 units of Lantus and 1.8 Lantus.

I am just relieved that my regular doctor was willing to listen to me and run the tests and she did not make me feel like an idiot for asking for them. I have not talked with her about it, I just went and picked the results up. I will go to the diabetes doctors in a couple of weeks and give the results to them. I'm sure they will tell me that I was foolish in asking for the tests to begin with, especially that snotty NP, but I don't care, it made me happy and put my mind at rest!
Thanks for the great link BadMoon, well written and very informative. I infer from it that the longer one fasts before a c-peptide the lower the result?
trtpup, that's the way I would read it, However the article also says "the meaning of a nonfasting C-peptide test that is normal or high (compared to a fasting reference range) is impossible to interpret." Apparently the reference given is only for a fasting test. Still a high number would seem to be an indication of significant production and with the other test results still points to sparkysmom being T2. I must admit this is stretching my arm chair endo credentials to the limit.




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