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Permalink Reply by Cosumne Jan on February 22, 2013 at 10:24pm

I found this article about Metformin very interesting, and even without the cancer references it explains how Metformin works very well.
http://www.lef.org/magazine/mag2012/feb2012_Can-Diabetes-Drug-Preve...

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Permalink Reply by jims on February 23, 2013 at 8:45am

Consumme Jan: thank you for this excellent articles from the Cancer Side.

Absolutely revealing.

Its time to take the valid research info and data stuffed in the Indiana Jones Government Warehouse and put to work.

From my perspective and the article I found, it confirmed what I had suspected that metformin is far more powerfull than currently peddled and the present taking of metformin in my mind is not facilitating its most important power.

Hey I am only a engineer, but we could use a better light on this mess and more open research and implementation of practical cures.

Best wishes and thank you for sharing!

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Permalink Reply by Cosumne Jan on February 23, 2013 at 8:53am

While I found the article interesting, the site that it's on seems questionable to me. I always wonder about sites that are selling things. I do know that some cancer doctors are prescribing metformin to their nondiabetic patients because I was surprised to find an aunt was taking it. My blood sugar stays at a fairly flat level because I eat low carb. Originally that was between 85-110 all day. Now it's within 95-120 for no reason that is easily apparent. I was prescribed metformin to help with this. It hasn't. Or maybe my BS would be even higher without it? I don't know.

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Permalink Reply by HPNpilot on February 23, 2013 at 9:21am

Agreed about the site. To check its validity, go to the references in the medical journals below it...and get the real data from the source.

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Permalink Reply by jims on February 23, 2013 at 9:39am

Well, that might be a good frame of reference, Metformin is being applied against cancer from articles I have seen many places. Whether or not the numbers are valid is a good question.

What is curious is that here we have a drug that leaves the body as it entered, no breakdown/cracking,digestion products and here is what it is doing.

Most curious. Signalling/catalyst?

Regarding your comments, my blood glucose never stayed flat and perisisted in drifting skyward all the time ( when no food left in intestine) and except when metformin was on board in blood stream. Hence "liver leak".

Metformin is not a cure all drug but one targeted at liver signalling monkeyshines.

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Permalink Reply by David (dns) on February 23, 2013 at 12:14am

I am T2 and take 1500 Metformin daily, including 500 at bedtime. Even so I have a pronounced DP that I counter with a small correction of Apidra on arising. I have never had a problem with overnight lows, but then I am not T1. Like most things concerning diabetes the only way to know for sure what will happen is to (cautiously) test it.

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Permalink Reply by jims on February 23, 2013 at 8:37am

My opinion is that metformin controls excess liver glucose release when it shouldnt be doing that. Metformin can help stop that.

If you do not have that issue T1 or T2 my guess is that metformin has no value to you - but here again an opinion from the peanut gallery and open to those experts on T1 and T2 issues to comment.

I do not get lows at night and the only time this may be an issue for me is under heavier exercise and larger glucose burn, the metformin to me seems to be shutting down the larger liver glucose release port and not the low level keep alive glucose release port of the liver as best as I have been told is on all the time.

I find a small dose of humalog lispro (u-100) at midnight is helful in keeping Dawn Phen. under control along with metformin doses of 500 mg at 10:00pm and 12:00am.

Best wishes and thank you for all the comments, data and thought.

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