My ISF has needed to be tweaked occasionally. But I don't know that I'd make a change based on one experience. But if you do, I would go ahead and make a small change. Say, if it's currently 1:30, change it to 1:35 and see how that does for awhile. For me I have quite different for different times a day - my daytime one is 1:30 and my night time one 1:60.
Changing your ISF factor should not impact your meal bolus / after meal BG unless you frequently have to include a correction amount with your meal bolus.
In that case, it's possible your IC (carb) ratio was off, but you didn't notice due to the incorrect ISF factor.
When you did your correction bolus for the 215, did you also eat, or did you just correct and then go to work ? If you did not eat, and 'getting' to work involved some degree of activity (even a small amount of walking), then that activity can 'supercharge' the correction bolus. So in that situation, you might want to keep your ISF factor as is, but when it calculates the bolus, reduce it down a bit when you know you will be active after the bolus.
I also think you need to see a pattern, rather than one occurrence, before concluding that your ISF factor needs to be changed. It should be based on doing a correction, not followed by a meal or activity.
I have correction factors for 8a-7p when I am active and a second one for 7p to 8a. It also depends on what you are doing.
How much activity did you have between correcting the 215 and re-checking two hours later?
One idea for the present, cut your bg correction in half and correct again in two hours, make detailed notes, then work with your endo to tweak your ISF.
When you take a correction with only basal, then there is no insulin on board.
IOB only comes from bolus.
Another possibility is that your 215 from you meter may have been off by 30-45 pts or so.
Every day there are variations, that can cause the unexpected highs and lows that you experienced, even when all your pump settings are 'right'. I think that's why a CGMS is so helpful ! But if they occur frequently, and you see patterns, then certainly consider some tweaking.