I have a type 2 friend on insulin who finds that Byetta works great when she uses it with metformin, but it doesn't work at all when used alone.
She took metformin alone for several years and found it had no effect on her attempts to lose weight. Then she added Byetta, and she said it was like a miracle.
She said she felt full after eating very little, didn't feel nauseous but
lost her interest in food. She said it was as if she'd had a brain
transplant, and she started losing weight without effort. It was wonderful.
Someone else said the same. With the combination she had the same normal appetite she'd had as a child. She was so happy she cried.
Then my friend had a kidney test, and it showed only 30% kidney function. You're not supposed to take metformin when your kidneys are impaired, so they took her off the metformin. Without the metformin, the Byetta didn't do a thing for her. Didn't affect her A1c, didn't help her eat less, didn't help her lose weight. So she dropped it.
Now she simply can't stop nibbling all day.
IOW, metformin alone didn't affect appetite. Byetta alone didn't affect appetite. But metformin plus Byetta worked wonders.
Has anyone else had a similar experience? I'm speaking primarly of weight loss here, not BG control.
Most of the research papers on Byetta used patients already on metformin, and it's FDA approved for use with metformin or sulfs or both, or TZDs, not as first-line therapy or for people using insulin, although there's a lot of "off label" use.