Byetta plus Metformin
She took metformin alone for several years and found it had no effect on her attempts to lose weight. Then she added Byetta, and she said it was like a miracle.
She said she felt full after eating very little, didn't feel nauseous but
lost her interest in food. She said it was as if she'd had a brain
transplant, and she started losing weight without effort. It was wonderful.
Someone else said the same. With the combination she had the same normal appetite she'd had as a child. She was so happy she cried.
Then my friend had a kidney test, and it showed only 30% kidney function. You're not supposed to take metformin when your kidneys are impaired, so they took her off the metformin. Without the metformin, the Byetta didn't do a thing for her. Didn't affect her A1c, didn't help her eat less, didn't help her lose weight. So she dropped it.
Now she simply can't stop nibbling all day.
IOW, metformin alone didn't affect appetite. Byetta alone didn't affect appetite. But metformin plus Byetta worked wonders.
Has anyone else had a similar experience? I'm speaking primarly of weight loss here, not BG control.
Most of the research papers on Byetta used patients already on metformin, and it's FDA approved for use with metformin or sulfs or both, or TZDs, not as first-line therapy or for people using insulin, although there's a lot of "off label" use.
Replies to This Discussion
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Permalink Reply by Christalyn on -
that is great your friend is having great success with byetta. I am taking it as well as metformin, and actos. I first started to lose the weight but the nausea began very unpredictable for me. earlier this week I had nausea and the normal GI "problems" from the metformin. Lately my numbers have not been great. So I believe my doctor will put my on insulin soon. The weight lose is steady....slow but steady.
Thanks for the article.....
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Permalink Reply by Jen on -
It's good to hear that your friend is having success with those medications. Unfortunately I haven't had such results though I wish I could. I'm on both Byetta and Metformin, though I'm only on the 5mc dose of Byetta. I did experience the disinterest in food when I was on the 10 but it caused me more problems than helped. My normal appetite is already very low and the increased disinterest with the Byetta would often cause me to not eat for 10 or 15 hours at a stretch. Just looking at food made me nauseous. I had to force myself to eat then struggle to keep it down. Needless to say it made my sugars harder to control and because of this and other reasons I didn't stick with the higher dose for long. With the lower dose things seem normal, appetite wise, but my weight loss isn't remarkable. I wish it were more successful as weight is an issue.
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