I have this happen to me once in a while.I start off by changing the tubing, resevoir, etc etc and when this doesn't work I try a new bottle of insulin but it takes awhile to realize what really is the problem. I also try an direct injection using the original bottle of insulin and if that all fails, then i try a fresh bottle of insulin-no real positive answer except that my sugars are sky high till i figure it all out-defnitely not a good thing.
It happens often to me :( its either the whole vial or wen i use the last insulin in it :( U just never know :(
I had this problem last year with a bottle of humilog. I had never considered the insulin being defected so like yourself i kept switching and changing out everything but the insulin. Unfortunately i wound up in the hospital for a week because my sugars were insanely high and my oxygen levels plummeted to near death levels. Always check your insulin if it looks cloudy!
I had some insulin go bad when I was travelling. I put the insulin in a refrigerator in my hotel room and it was too cold. I was also camping and it was extremely hot. The extreme temperatures damaged the insulin and it went cloudy. I was on on a 30/70 mix, injecting twice a day and it was the long acting insulin that was damaged. The result was that I was going into some terrible lows until I realized what had happened. I am now on a pump and carry my insulin in a frio pack and never trust a hotel refrigerator.
The analog insulins are more sensitive to temperature.
I have gone to pick up insulin at the pharmacy and could see that it was sitting on the counter for pick up. It probably had been there for days.
I buy 3 bottles at a time so the third bottle will be a month away from use, When I see this happen I insist that they get me new bottles. You never know what happens before you get it.
I only had it go bad once. It still worked but I needed to bolus almost twice my usual. I switched to a new bottle and it was fine.
I know that Novolog will send you a free coupon for a bottle if you send them an email and tell them your bottle went bad. That is what I did with mine.