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Otelixizumab (TRX-4) Trial Participants


Otelixizumab (TRX-4) Trial Participants

Group for people who have participated in any of the trials with otelixizumab. Such as DEFEND, DEFEND-2, TTEDD and all the other ones at are coming out.

Please share your changes in insulin, BG, A1C, your experiences on the trial.

Members: 12
Latest Activity: Nov 2, 2013

Diabetes Forum

Wow, didn't expect this....

Started by lindanu. Last reply by t.clayton Apr 27, 2011. 3 Replies

LONDON—GlaxoSmithKline PLC and its U.S. partner Tolerx Inc. Friday said their experimental drug otelixizumab failed to pass a late-stage clinical trial for Type 1 diabetes.The two companies in a…Continue

First MMTT since dosing

Started by lindanu. Last reply by lindanu Mar 10, 2011. 10 Replies

So we went in four the first MMTT since dosing. He had an MMTT twice prior to dosing. the first time his BG was 122 in the morning and 244 two hours after the boost. That was three weeks after…Continue

Answer to Julie's Email

Started by SuFu, Ph.D.. Last reply by samsmom Feb 28, 2011. 10 Replies

Julie,I hope you don't mind but I'll start a discussion form so that we can all benefit from the replies. If you son received the drug, that is not an uncommon response. There are two other people at…Continue

Honeymoon or study drug?

Started by lindanu. Last reply by lindanu Feb 21, 2011. 2 Replies

I posted this on 'parent's of kids' but decided to move it here.Wow Julie, you son had an immediate response!! Yesterday my son had very little insulin. He woke up at 101 and had 65 carbs and 2…Continue

Comment Wall


You need to be a member of Otelixizumab (TRX-4) Trial Participants to add comments!

Comment by SuFu, Ph.D. on July 6, 2012 at 8:40am

Nothing so far on my end either. I just emailed the coordinator so we'll see if anything comes from that.

Comment by lindanu on June 7, 2012 at 9:02am

No, they have not said anything about following up with him. Gosh i wish he could get another dose, I swear it made a difference. Last year at this time he was taking about 6 units of humulog per day.

Comment by samsmom on June 5, 2012 at 5:07pm

Haven't heard anything yet. Do they plan to follow up with him at all?

Comment by lindanu on June 5, 2012 at 10:50am

Just got a call from our endo. Study is unblinded. Reece did get the drug. Anyone else hear?

Comment by samsmom on February 11, 2012 at 10:53am

This drug, otelixizumab, has been used in trials in Europe also. Our trial here is ending because the research shows it didn't perform as expected. The hope was that it would extend the "honeymoon" phase where the Type 1 patient is still producing some of their own insulin. There are similar drugs currently in trials. If you google otelixizumab, you'll see the related news. Another drug tried this way is teplizumab. I see a lot of research focusing on the honeymoon phase, or stopping the body's autoimmune attack. The thing about these trials is that you have to sign up right after diagnosis.

Comment by NICKOLE on February 10, 2012 at 1:35pm

Hi, iam in England.....My friend lives in Romania. In my country is not a lot of information about this drug.

Comment by samsmom on February 7, 2012 at 4:23pm

Nickole, we're talking about a drug tested in a clinical trial here in the U.S. Where are you? You can check for drug trials online -- or try contacting a diabetes organization where you are for information.

Comment by NICKOLE on February 7, 2012 at 4:28am
Hello, how can my friend trye that medicine? They know in my country about this but they dont do nothing...the dr just they give a diet to the boy and that it.They dont care what is next they just shut the eye.
Comment by lindanu on January 17, 2012 at 3:44am

we got the letter which says it officially ends in March 2012. It doesn't mention telling us, but i'm sure they will. I think my endo considers very little insulin a honeymoon.

Comment by samsmom on January 16, 2012 at 5:03pm

Just got back from our trial check-up. Dr said they have results showing that there is no difference between the drug group and the control group. He said they have determined that there are no adverse effects after the one-year mark, so that's why there's no reason to follow patients after visit 12. I said, "Did Samantha have a long honeymoon on her own?" He said, "She didn't have a honeymoon." He considers it no honeymoon since she has required insulin - it doesn't matter how much. He said he's not sure if they will tell us who got the drug: there is some letter that is already written & ready to go but it will take months to go through the proper channels. So -- we have one more visit in Feb.


Members (12)




From the Diabetes Hands Foundation blog...

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Diabetes Hands Foundation is incredibly honored to join the Diabetes Advocacy Alliance, an organization with the drive and potential to affect a powerful, positive impact on diabetes and healthcare policy. Diabetes Advocacy Alliance is a 20-member coalition of leading professional Read on! →

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HELMSLEY CHARITABLE TRUST GRANTS SUPPORT TO DIABETES HANDS FOUNDATION FOR FOURTH YEAR  Funding in 2015 to support major transitions in programs and leadership at Diabetes Hands Foundation BERKELEY, CA: February 18, 2015 – The Leona M. and Harry B. Helmsley Read on! →

Diabetes Hands Foundation Team


Melissa Lee
(Interim Executive Director, Editor, has type 1)

Manny Hernandez
(Co-Founder, has LADA)

Emily Coles (Head of Communities, has type 1)

Mila Ferrer
(EsTuDiabetes Community Manager, mother of a child with type 1)

Mike Lawson
(Head of Experience, has type 1)

Corinna Cornejo
(Director of Operations and Development, has type 2)

Desiree Johnson  (Administrative and Programs Assistant, has type 1)


Lead Administrator

Brian (bsc) (has type 2)


Lorraine (mother of type 1)
Marie B (has type 1)

DanP (has Type 1)

Gary (has type 2)

David (has type 2)


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