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I ran across this old 2005 article at DiabetesHealth.com
I thought this section was interesting:
Take Symlin as you start eating the main part of your meal. Symlin seems to produce its satiety effect within 10 to 15 minutes after injection, although each patient’s response may vary. If the meal starts with an appetizer or soup and salad, the patient can consider waiting until the main course is served. This recommendation comes from feedback given during the clinical trials. If Symlin is taken too early and the pre-meal insulin dose has already been given, the risk of after-meal hypoglycemia may go up.