Replies to This Discussion

Permalink Reply by Sarah on April 5, 2010 at 3:20pm

Makes perfect sense.. I've noticed lately after a workout, even if my BG was stable throughout, I will skyrocket over the hour or so following.

Permalink Reply by TS on April 20, 2010 at 2:12pm

If anyone is interested, I sort of tried this - I tried 15 ug (I usually take 45 for a meal) - and boy was I sick! But, 15 ug results in more nausea than 45 for me, don't know why. Add 15 ug to a hard workout (50 min of weight lifting to failure) and I did not like the stomach cramps at all.
I will probably try it again after a long aerobic workout - more than 2 hr of a hard workout and my BG rise steadily afterwords, so 15-30 ug of Symlin might do the trick (or I might kill myself, but that's neither here nor there!).

Permalink Reply by Katrina Schindler on July 21, 2010 at 4:46pm

This is a really good question! I just started taking Symlin 2 weeks ago and was up to 120 mg/meal by day 3 (I’m insulin resistant Type I so I’m thinking I might be amylin resistant too?) and only get nausea in the mornings – but I love that I’m not obsessed with food all the time now!!

I was reading the article that you reference and it says “exercise stimulates amylin secretion in well-trained individuals…” so I was thinking it might work to take Symlin either right before exercise or about 10 minutes after starting?? I still get post-exercise spikes and am guessing it is from a non-regulated glucagon response. I do wait about 2 hours after eating to go exercise because I don’t want to crash while the Symlin is still working and the insulin from my meal is peaking, and am thinking that another shot of Symlin right after starting to exercise might regulate the glucagon response and remain active through the recovery period (assuming Symlin has a 2-hour life and assuming a 1-hour workout session) without making you crash because it’s just working with your basal rate (assuming you’re on a pump).

Anyway, I was just wondering if you had any further comments about doing this or if anyone else has experimented with Symlin and exercise and timing and all that good stuff!

Permalink Reply by TS on July 22, 2010 at 7:55am

I need to try it again some more. One thing that is definitely true with Symlin is that it takes a month or more for it to settle down. It has no obvious effect on me anymore, but my A1c has dropped from 7.1 to 5.8 in 3 months of using it and I feel great!
I have not been using it for exercise, but, I think using it for 1 or 2 meals/day has even affected post exercise trouble I used to have. Everything is just more balanced now, extreme highs which I used to have for no obvious reason are all but gone.