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U500 Insulin

Fast acting insulin that works on insulin resistance diabetes.

Please note: the exchange, sale or giveaway of items between members that require a prescription from a licensed practitioner, including insulin, is not allowed on TuDiabetes.

We encourage you to donate supplies to non-profits such as the Charles Ray III Diabetes Association and Insulin for Life, which accept insulin and other diabetes-related supplies.

You can also approach your physician's office or local medical groups to discuss donating them to those in need of assistance in your area.

Members: 18
Latest Activity: Sep 16, 2014

Diabetes Forum


Started by jeremiahtren. Last reply by n1njahczar Sep 16, 2014. 4 Replies

How is this strength insulin affecting you? Do you have to special order it the way me and my daughter do? If you re on the pump whats your basal?Continue

I am on the Humana Gold Medicare I am in the Gap ? What can be done ?

Started by GaryG. Last reply by GaryG Aug 25, 2014. 1 Reply

U500 seems to be working I have been on it I think over 3 Years. I went on Medicare September 2013 I signed up with Medicare Part D. through Humana. Here it is the end of August because I am in the…Continue

Comment Wall


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Comment by cattiecannslugg on June 11, 2014 at 1:54am

I don't know if there's going to be a comment on this but I've been using U500 insulin consistently for about 3 years now. It's not my favorite insulin but it seems to do the job. I inject 3 times a day, 14 AM, 13 Lunch, & a sliding scale ranging from 7 to 10+ units at bedtime. I've had such weight gain with this insulin. I'm going to say about 75 lbs. over the 3 years I've been on it. I mean I'm not the best at watching what I eat, but I've gotten better and I move. I don't sit around all day and watch TV. I'm constantly moving and doing stuff. Anyway, my last A1c was the best it's been my whole diabetes "career" --- 7.4!!! I couldn't believe it. I was quite shocked. It's good shock. I don't have a pump and my pharmacy auto-orders this special insulin for me. I love my pharmacy and pharmacists. I think this is all I have to say right now. What got me was the weight gain. But then it dawned on me this insulin is super concentrated. Duh! to me. I inject a whole lot of insulin. Oh, my other insulin is Novolog. Correction ratios is 1:10 over 130 and my Meal is 1:3 for breakfast and lunch and dinner is 1:2. I also take metformin (750 mg). Anywho, thanks for listening.

Comment by Pamela Smith on June 10, 2013 at 1:11pm

Hi Everyone! I've been using U500 since September of 2012. I've had a few issues with it. Most noticably was that it allowed by pump educator and endo to really increase my hourly rate with the pump. From September3rd to November 16th I gained 46 pounds when my rate went up by 20%. I'm also finding that it isn't as fast acting as U100 and I've had issues with stacking as a result. Anyone else? I should say that I love that I'm not having to refill a cartridge every 16-18 hours anymore but I'm not sure I'm happy with it overall. I'm down to 60 carbs a day and keep reducing the basal rate so that I can hopefully go back to U100 as I found it more stable.

Comment by Chel on March 12, 2013 at 6:09pm

I just have a question and I hope I am posting it in the right section of this group. I am going to be switching to u500 insulin next week, & I am currently on a pump, but I would like to go back to injections once I get the u500. My question is, what kind of N insulin will I use with the u500? And if I was on 100 units of Lantus twice a day when injecting Novolog for meal time, will I require less N insulin or would I still do the Lantus, 200 units daily? I know, this is a question for my doc, but I was just curious if anyone could maybe give me an idea. Thanks!

Comment by netbadger on September 2, 2012 at 2:04pm

Wow CWDancer! Sorry to hear about all of your problems with the insulin and your insurance company. I had all sorts of problems in getting approval when I was with Humana. I am with Florida Healthcare HMO, A company bought by Blue Cross Blue Shield. They approved it right away, but my co-pay of 15% works out to be $101 a bottle. There is hope on the low blood sugars. I had problems with that when I first started, but my last four A1C numbers were 6.5, 6.7, 7.1, & 7.3. The first was my most recent. My diabetes doc wanted it under 7, so I am on target finally. Mine used to be in the 8's and 9's too. To get good control and not get the low BS readings, I check my blood 6 to 8 times a day. That way it doesn't stay too high or too low for very long. The other thing is watching the carb labels like a hawk. Also be sure to deduct the grams of fiber from the carb total, or you will end up giving yourself too nuch insulin.

Comment by netbadger on September 2, 2012 at 1:44pm

Comment by CWDancer on September 1, 2012 at 6:40pm

Iwas utn U500 several months ago because I have extreme insulin senstvity. We have to use this until my insurance decides to over it. We have been fighting them fo ove a year. Because o the insulin resistance and my autoimmune reaction to the isulin my doctor has had to raise my levels many times. The main side effect of the U500 is low lood sugar but mine is still up. My last A1c was 8.9. my highest A1c was 9.8.

Comment by netbadger on September 1, 2012 at 8:18am

When you are first started on U500, did it make you ravenously hungry all of the time? Are you still hungry all of the time?

Comment by terryb1967 on December 10, 2011 at 2:30pm

Have been put on U-500 it is working better but still need to figure out some snags, as of right now my carb ratio is 15 and my sensitivity is 50 and my basal rate is 1.0 but my sugar are still running above 150. I am trying to count the carbs but something isn't matching up.

Comment by jeremiahtren on August 23, 2010 at 7:11pm
welcome candyberry!!!!!
Comment by jeremiahtren on August 23, 2010 at 2:36pm
ok i just got it.cost me 300 bucks! and thanks for the warning sometimes iam prone to hypo and dont even reconize it until my bs is in the 30s

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