There are several digestive hormones that relate to blood sugar and appetite control including Amylin (which Symlin is for), Glucagon-like peptide hormone-1 (which Victoza is 97% like the human form of GLP-1), leptin, grehlin, and more.
Each digestive hormone helps in a different, but similar way with the digestive process. Some help with stomach rate of digestion. Some help with appetite suppression. Some help tell a functioning pancreas to secrete insulin when food is present. Some shut off glucgagon which makes the liver stop producing (as much) sugar after meals. There are receptors all over the body and each hormone works in different ways in different body parts, though some of their actions seem to overlap. :o)
Symlin is very short acting (about 4 hours) where Victoza lasts about 26 hours, so people like taking 1 injection/day vs. 3/day. Symlin more 'dramatically' 'covers' meal time BG spikes, Victoza more 'dramatically' 'covers' basal insulin (because of decreased glucagon and liver sugar).
However, I would love to hear more about what people actually comparing Symlin to Victoza actually find with their BGs after meals, overnight, between long periods without eating, etc.
It would be interesting to see what would happen if Katrina ever tried Victoza instead of Symlin. I'd love to know what your tolerence, satiety, side effects, low BG issues, digestion rate, etc. would be like comparing Symlin to Victoza individually and not simultaneously.
If anyone else switched from Symlin to Victoza, please feel free to elaborate!! :o)
I am a T1 on Victoza and love it. I split my daily dose into two injection 12 hours apart. The pharmacodynamics of Victoza shows a peak plasma concentration at about 8-12 hours after injection which may or may not be seen in your sugars depending on you rates and sensitivity. If you experience lower BG's 8-12 hours after injection like I did, consider splitting the dose. This works beautifully for me because the effects are soooooo stable, no peak and no wear off. It mostly helps to reduce your dependence on insulin for your basals. I found this most helpful during activity. Having less insulin in my system at any one time makes me less susceptible to lows from increased activity and light exercise, like walking my dog or riding my bike to school. I still need a temp 50% basal before going to the gym or any extended/moderate to heavy exercise - group exercise classes for example.
Thanks Richelle. I'm a LADA and my ENDO suggested I try Victoza because of my insulin resistance. I'm on 1.2mg and have reduced my total daily insulin use by about 30%. I'm going to try splitting the dose like you suggest as I'm having some issues with lows due to exercise as well as unexpected lows in the afternoon (about 8 hours after my morning dose). I'm still experimenting, but it seems to be working for me.
If your main problem is insulin resistance, you might ask about metformin instead of Victoza. Victoza just reduces glucagon, but doesn't have any direct effect on cell's ability to take up glucose. Metformin does, so it might be a better fit. Ask your endo about it.