Replies to This Discussion

Permalink Reply by Isabelle Barbara on October 19, 2011 at 8:44am

Hi Sophia, 20 lbs is very good !!! I read a lot of posts but about people with T2 and they said that they stop loosing weight when they reach their normal weight. That will be nice, something that allow you to loose just what you need !! Surrealistic? Is the case with you?

Permalink Reply by sophiaofthrace on October 19, 2011 at 10:32am

I still have quite a bit more to lose to get to where I want to be, but I also have other medical challenges. I am T1 though. The impression I have gotten is that the appetite suppression only lasts for a short time (several weeks or a few months), then you have to increase the dose. Once you get to the maximum dose, if you still need to lose weight, you have to look for additional options. I suppose it is a little different for everyone.

Permalink Reply by Isabelle Barbara on October 20, 2011 at 3:42am

Thanks Sophia

Permalink Reply by TV on December 31, 2012 at 5:12pm

There are several digestive hormones that relate to blood sugar and appetite control including Amylin (which Symlin is for), Glucagon-like peptide hormone-1 (which Victoza is 97% like the human form of GLP-1), leptin, grehlin, and more.

Each digestive hormone helps in a different, but similar way with the digestive process. Some help with stomach rate of digestion. Some help with appetite suppression. Some help tell a functioning pancreas to secrete insulin when food is present. Some shut off glucgagon which makes the liver stop producing (as much) sugar after meals. There are receptors all over the body and each hormone works in different ways in different body parts, though some of their actions seem to overlap. :o)

Symlin is very short acting (about 4 hours) where Victoza lasts about 26 hours, so people like taking 1 injection/day vs. 3/day. Symlin more 'dramatically' 'covers' meal time BG spikes, Victoza more 'dramatically' 'covers' basal insulin (because of decreased glucagon and liver sugar).

However, I would love to hear more about what people actually comparing Symlin to Victoza actually find with their BGs after meals, overnight, between long periods without eating, etc.

It would be interesting to see what would happen if Katrina ever tried Victoza instead of Symlin. I'd love to know what your tolerence, satiety, side effects, low BG issues, digestion rate, etc. would be like comparing Symlin to Victoza individually and not simultaneously.

If anyone else switched from Symlin to Victoza, please feel free to elaborate!! :o)
Thanks!

Permalink Reply by richelle on January 9, 2012 at 5:18pm

I am a T1 on Victoza and love it. I split my daily dose into two injection 12 hours apart. The pharmacodynamics of Victoza shows a peak plasma concentration at about 8-12 hours after injection which may or may not be seen in your sugars depending on you rates and sensitivity. If you experience lower BG's 8-12 hours after injection like I did, consider splitting the dose. This works beautifully for me because the effects are soooooo stable, no peak and no wear off. It mostly helps to reduce your dependence on insulin for your basals. I found this most helpful during activity. Having less insulin in my system at any one time makes me less susceptible to lows from increased activity and light exercise, like walking my dog or riding my bike to school. I still need a temp 50% basal before going to the gym or any extended/moderate to heavy exercise - group exercise classes for example.

Permalink Reply by David on June 11, 2012 at 9:22am

Thanks Richelle. I'm a LADA and my ENDO suggested I try Victoza because of my insulin resistance. I'm on 1.2mg and have reduced my total daily insulin use by about 30%. I'm going to try splitting the dose like you suggest as I'm having some issues with lows due to exercise as well as unexpected lows in the afternoon (about 8 hours after my morning dose). I'm still experimenting, but it seems to be working for me.

Permalink Reply by richelle on January 9, 2012 at 5:20pm

If your main problem is insulin resistance, you might ask about metformin instead of Victoza. Victoza just reduces glucagon, but doesn't have any direct effect on cell's ability to take up glucose. Metformin does, so it might be a better fit. Ask your endo about it.

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